cancer
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Thursday, July 6th, 2006Epigenomics AG released clinical data this week showing that a new approach to early colorectal cancer detection in blood can be used to detect most colon polyps.Colon polyps are benign proliferations that can give rise to cancer. The risk is considerably high if they are greater than 1 cm in size. Their timely removal is [...]
Epigenomics to Use Affymetrix Platform
Wednesday, June 28th, 2006Epigenomics AG has announced that it will use Affymetrix microarray technology in its in-vitro diagnostic (IVD) tests for oncology and other indications. The Affymetrix technology, along with Epigenomics’ previously announced alliance with Qiagen for sample preparation, will allow for Epigenomics to provide a “complete platform” for its DNA methylation marker pathology tests.
The first use of [...]
Hypermethylation of WRN Gene Promoter Linked to Human Cancer
Sunday, June 25th, 2006New research published in the Proceedings of the National Academy of Sciences suggests that increased methylation of the promoter sequence of the WRN gene is highly correlated with inactivation of the gene in human cancer cell lines.In this manuscript, we demonstrate that WRN undergoes CpG island promoter methylation-associated gene silencing in human cancer cells. The [...]
New Advances in Epigenetics and Cancer
Thursday, June 22nd, 2006Therapeutics Daily provides a summary of several recent research articles published involving new discoveries into the epigenetic mechanisms that contribute to the onset and spread of certain cancers. In one study, researchers report that epigenetically silenced tumor suppressors overcome resistance to apoptosis induction by interferons. The other studies probe for new insights into the [...]
New Genetics Carnival: Mendel’s Garden
Monday, June 19th, 2006A new carnival devoted to covering the latest writing in the realm of genetics, Mendel’s Garden, has published its debut edition at The force that through…. Among the myriad of links included is one to a primer on a interference RNA (RNAi), including microRNA (miRNA), that may provide some helpful background information pertaining to the [...]
microRNA Inhibits Cancer Gene in Human Cancer Cells
Monday, June 12th, 2006The June edition of Cancer Cell offers new research from Peter A. Jones and colleagues that “demonstrates that agents known to regulate gene expression can also impact regulatory RNAs that may function as tumor suppressors in normal cells and proposes a novel strategy for treating human cancers.”DNA methylation and histone deacetylation are epigenetic processes involved [...]
Endocrine Disruptors and Epigenetics in an Evolutionary Perspective
Monday, June 12th, 2006Evolutionary biologist David Crews and colleague John McLachlan have published an interesting paper in the endocrine disruptor supplement in the June edition of the journal Endocrinology entitled “Epigenetics, Evolution, Endocrine Disruption, Health, and Disease.” The paper takes a closer look at some of the key research findings made in the last year in the area [...]
Epigenomics and Stanford Collaborate on Colorectal Cancer Detection
Friday, June 9th, 2006Epigenomics and the Molecular Imaging Program at Standord (MIPS) have announced an agreement to collaborate in the area of colorectal cancer detection. The research will aim to complement the benefits of both colorectal cancer detection using methylation markers and detection using positron emission tomography (PET).
Positron emission tomography (PET) is a medical imaging technique which produces [...]
Early Estrogen Exposure Increases Risk of Prostate Cancer
Thursday, June 1st, 2006New research published in the June 1 edition of Cancer Research shows that low doses of bisphenol A (BPA) delivered to female rats during pregnancy increases the risk of their male offspring developing prostate cancer later in life. The cause was found to be associated with the elevated level of eastradiol in the aging male [...]
Epigenetics in Nature
Thursday, May 11th, 2006Nature has posted an interesting article entitled “Epigenetics: Unfinished Symphony” [subscription required]. Beginning with a look at how epigenetics has been explored in identical twin studies, the article also takes a current look at the International Human Epigenome Project and its efforts to gain funding, better organization, and credibility as a worthwhile effort.
Given…technological challenges, [...]
Methylation “suburbs” implicated in colorectal cancer
Monday, April 24th, 2006Nature Genetics has published ahead of print a research article providing new insight into the role that epigenetics plays in the aetiology of colorectal cancer. A research group led by Dr. Susan J. Clark of Garvan Institute of Medical Research in Australia have correlated the global gene suppression of chromosome 2q.14.2, spanning four Mb, [...]
The History of Epigenetics Explored
Saturday, April 15th, 2006The second issue of the Journal of Epigenetics is now (partially) available online, with free online access to this new journal through the end of 2006. The issue contains an informative historical overview of the field of epigenetics, beginning with the coinage of the term “epigenetics” by Conrad Waddington to help merge the fields [...]
Predicting Recurrence of Prostate Cancer
Wednesday, April 5th, 2006A new study shows that a test checking for hypermethylation of a single gene can predict recurrence of prostate cancer in patients who have had their glands surgically removed. Epigenomics AG announced today that in a clinical study of 605 prostate cancer patients, those patients who tested positive for hypermethylation of the PITX2 gene [...]
Methylation marker for colorectal cancer detection
Monday, April 3rd, 2006New data shows that colorectal cancer can be detected early by a free-floating blood test looking for a methylated version of the septin 9 gene. Molecular genomics company Epigonomics AG announced that it has completed a set of studies showing that “presence of the methylated form of DNA encoding the so-called Septin 9 gene [...]
Epigenetics implicated in clinical anti cancer resistance
Monday, March 20th, 2006A research team with the Centre of Oncology and Applied Pharmacology at Glasgow University postulate an epigenetic mechanism in driving polygenic resistance in cancer patients. Read more…
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