research articles
« Previous Entries Next Entries »Epigenetic modifications and chromatin loop organization explain the different expression profiles of the Tbrg4, WAP and Ramp3 genes.
Friday, February 29th, 2008Montazer-Torbati MB, Hue-Beauvais C, Droineau S, Ballester M, Coant N, Aujean E, Petitbarat M, Rijnkels M, Devinoy EExp Cell Res (Mar 2008)
Whey Acidic Protein (WAP) gene expression is specific to the mammary gland and regulated by lactogenic hormones to peak during lactation. It differs markedly from the more constitutive expression of the two flanking genes, Ramp3 and Tbrg4. Our results show that the tight [...]
Epigenetic regulation of telomerase in retinoid-induced differentiation of human leukemia cells.
Monday, February 25th, 2008Love WK, Berletch JB, Andrews LG, Tollefsbol TOInt J Oncol (Mar 2008)
Changes in the promoter methylation of hTERT, the gene that encodes telomerase, a ribonucleoprotein responsible for replacing telomeric repeats, have been demonstrated in differentiating cells where hTERT is inhibited, suggesting epigenetic regulation of hTERT. All-trans retinoic acid (ATRA) induces differentiation in human leukemia cells and has had significant [...]
Cutting Edge: TGF-{beta}-Induced Expression of Foxp3 in T cells Is Mediated through Inactivation of ERK.
Monday, February 25th, 2008Luo X, Zhang Q, Liu V, Xia Z, Pothoven KL, Lee CJ Immunol (Mar 2008)
The peripheral induction of T regulatory cells can be accomplished by TGF-beta through an epigenetic regulation leading to the expression of Foxp3. However, the exact mechanism of such a TGF-beta-mediated action remains unclear. In the current study, we found that TGF-beta treatment of CD4(+)CD25(-) T cells during [...]
The power of the word may reside in the power of affect.
Monday, February 25th, 2008Panksepp JIntegr Psychol Behav Sci (Mar 2008)
This commentary on Dan Shanahan’s, A New View of Language, Emotion and the Brain, basically agrees with an emotion-based view of the evolutionary and developmental basis of language acquisition. It provides a supplementary neuroscience perspective that is more deeply affective and epigenetic in the sense that all claims about neocortically-based [...]
The Hsp90 molecular chaperone: an open and shut case for treatment.
Monday, February 25th, 2008Pearl LH, Prodromou C, Workman PBiochem J (Mar 2008)
The molecular chaperone Hsp90 (90 kDa heat-shock protein) is a remarkably versatile protein involved in the stress response and in normal homoeostatic control mechanisms. It interacts with ‘client proteins’, including protein kinases, transcription factors and others, and either facilitates their stabilization and activation or directs them for proteasomal degradation. By [...]
Lyl1 interacts with CREB1 and alters expression of CREB1 target genes.
Monday, February 25th, 2008San-Marina S, Han Y, Suarez Saiz F, Trus MR, Minden MDBiochim Biophys Acta (Mar 2008)
The basic helix-loop-helix (bHLH) transcription factor family contains key regulators of cellular proliferation and differentiation as well as the suspected oncoproteins Tal1 and Lyl1. Tal1 and Lyl1 are aberrantly over-expressed in leukemia as a result of chromosomal translocations, or other genetic or epigenetic events. Protein-protein and protein-DNA [...]
MicroRNA epigenetic alterations in human cancer: one step forward in diagnosis and treatment.
Saturday, February 23rd, 2008Yang N, Coukos G, Zhang LInt J Cancer (Mar 2008)
MicroRNAs (miRNAs) are approximately 22 nt non-coding RNAs, which regulate gene expression in a sequence-specific manner via translational inhibition or messenger RNA (mRNA) degradation. Since the discovery of their fundamental mechanisms of action, the field of miRNAs has opened a new era in the understanding of small noncoding RNAs. [...]
Further characterization of the first seminoma cell line TCam-2.
Saturday, February 23rd, 2008de Jong J, Stoop H, Gillis AJ, Hersmus R, van Gurp RJ, van de Geijn GJ, van Drunen E, Beverloo HB, Schneider DT, Sherlock JK, Baeten J, Kitazawa S, van Zoelen EJ, van Roozendaal K, Oosterhuis JW, Looijenga LHGenes Chromosomes Cancer (Mar 2008)
Testicular germ cell tumors of adolescents and adults (TGCTs) can be classified into seminomatous and nonseminomatous tumors. Various nonseminomatous cell lines, predominantly embryonal carcinoma, have been established and proven to be valuable for pathobiological and clinical [...]
Using metastasis suppressor proteins to dissect interactions among cancer cells and their microenvironment.
Saturday, February 23rd, 2008Taylor J, Hickson J, Lotan T, Yamada DS, Rinker-Schaeffer CCancer Metastasis Rev (Mar 2008)
Cancer metastasis is a complex, dynamic process that begins with dissemination of cells from the primary tumor and culminates in the formation of clinically detectable, overt metastases at one or more discontinuous secondary sites. Evidence from in vivo video microscopy as well as PCR and immunohistochemical studies [...]
Germline hypermethylation of the APC promoter is not a frequent cause of familial adenomatous polyposis in APC/MUTYH mutation negative families.
Saturday, February 23rd, 2008Romero-Gimnez J, Dopeso H, Blanco I, Guerra-Moreno A, Gonzalez S, Vogt S, Aretz S, Schwartz S, Capella G, Arango DInt J Cancer (Mar 2008)
Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome predisposing to colorectal cancer and affects 1 in 5-10,000 births. Inheritance of a mutant allele of the adenomatous polyposis coli (APC) gene is the cause of approximately 80% of FAP and 20-30% of [...]
Aberrant DNA methylation imprints in aborted bovine clones.
Saturday, February 23rd, 2008Liu JH, Yin S, Xiong B, Hou Y, Chen DY, Sun QYMol Reprod Dev (Apr 2008)
Genomic imprinting plays a very important role during development and its abnormality may heavily undermine the developmental potential of bovine embryos. Because of limited resources of the cow genome, bovine genomic imprinting, both in normal development and in somatic cell nuclear transfer (SCNT) cloning, is not [...]
Frequent epigenetic inactivation of hSRBC in gastric cancer and its implication in attenuated p53 response to stresses.
Saturday, February 23rd, 2008Lee JH, Byun DS, Lee MG, Ryu BK, Kang MJ, Chae KS, Lee KY, Kim HJ, Park H, Chi SGInt J Cancer (Apr 2008)
hSRBC is a putative tumor suppressor located at 11p15.4, at which frequent genomic loss has been observed in several human malignancies. To explore the candidacy of hSRBC as a suppressor of gastric tumorigenesis, we analyzed the expression and mutation status of hSRBC [...]
p16(INK4A) genetic and epigenetic profiles differ in relation to age and site in head and neck squamous cell carcinomas.
Saturday, February 23rd, 2008O’Regan EM, Toner ME, Finn SP, Fan CY, Ring M, Hagmar B, Timon C, Smyth P, Cahill S, Flavin R, Sheils OM, O’Leary JJHum Pathol (Mar 2008)
Head and neck squamous cell carcinoma (HNSCC) typically affects male smokers older than 55 years. Recently, an increase in the incidence of HNSCC in young adults has been recognized, many of them nonsmokers and females. Functional inactivation of p16 is known [...]
Evidence for the absence of meiotic silencing by unpaired DNA in Neurospora tetrasperma.
Saturday, February 23rd, 2008Jacobson DJ, Raju NB, Freitag MFungal Genet Biol (Mar 2008)
Meiotic silencing by unpaired DNA is a posttranscriptional gene silencing process in Neurospora crassa. Any gene without a homolog in the same chromosomal position during meiotic prophase generates a sequence-specific signal that prevents expression of all copies of that gene, but only during meiosis. Meiotic silencing is epigenetic and [...]
Recruitment of Drosophila Polycomb-group proteins by Polycomblike, a component of a novel protein complex in larvae.
Saturday, February 23rd, 2008Savla U, Benes J, Zhang J, Jones RSDevelopment (Mar 2008)
Polycomb-group (PcG) proteins are highly conserved epigenetic transcriptional repressors that play central roles in numerous examples of developmental gene regulation. Four PcG repressor complexes have been purified from Drosophila embryos: PRC1, PRC2, Pcl-PRC2 and PhoRC. Previous studies described a hierarchical recruitment pathway of PcG proteins at the bxd Polycomb Response [...]
