research articles
« Previous Entries Next Entries »Genetic evidence that Ras-like GTPases, Gtr1p, and Gtr2p, are involved in epigenetic control of gene expression in Saccharomyces cerevisiae.
Sunday, March 30th, 2008Sekiguchi T, Hayashi N, Wang Y, Kobayashi HBiochem Biophys Res Commun (Apr 2008)
Gtr1p and Gtr2p of Saccharomyces cerevisiae are members of the Ras-like GTP binding family and interact genetically with Prp20p (yeast RCC1), which is a guanine nucleotide exchange factor for Gsp1p (yeast homolog of Ran, involved in nuclear export). Recently, Gtr1p and Gtr2p were suggested to be molecular [...]
Promoter analysis of epigenetically controlled genes in bladder cancer.
Sunday, March 30th, 2008Veerla S, Panagopoulos I, Jin Y, Lindgren D, Hglund MGenes Chromosomes Cancer (May 2008)
DNA methylation is an important epigenetic modification that regulates several genes crucial for tumor development. To identify epigenetically regulated genes in bladder cancer, we performed genome wide expression analyses of eight-bladder cancer cell lines treated with the demethylating agents 5-aza-2′-cytidine and zebularine. To identify methylated C-residues, we [...]
Developmental capacity of porcine nuclear transfer embryos correlate with levels of chromatin-remodeling transcripts in donor cells.
Monday, March 3rd, 2008Magnani L, Lee K, Fodor WL, Machaty Z, Cabot RAMol Reprod Dev (May 2008)
Somatic cell nuclear transfer (SCNT) still retains important limitations. Impaired epigenetic reprogramming is considered responsible for altered gene expression and developmental failure in SCNT-derived embryos. After nuclear transfer the donor cell nucleus undergoes extensive changes in gene expression that involve epigenetic modifications and chromatin remodeling. We hypothesized [...]
The XVth World Congress of Psychiatric Genetics, October 7-11, 2007: Rapporteur summaries of oral presentations.
Monday, March 3rd, 2008Alkelai A, Baum A, Carless M, Crowley J, Dasbanerjee T, Dempster E, Docherty S, Hare E, Galsworthy MJ, Grover D, Glubb D, Karlsson R, Mill J, Sen S, Quinones MP, Vallender EJ, Verma R, Vijayan NN, Villafuerte S, Voineskos AN, Volk H, Yu L, Zimmermann P, Delisi LEAm J Med Genet B Neuropsychiatr Genet (Mar 2008)
The World Congress of Psychiatric Genetics (WCPG) has become an annual event since the early 1990’s sponsored by the International Society of Psychiatric Genetics [...]
Transgenerational effects of the endocrine disruptor vinclozolin on the prostate transcriptome and adult onset disease.
Monday, March 3rd, 2008Anway MD, Skinner MKProstate (Apr 2008)
PURPOSE: The ability of an endocrine disruptor exposure during gonadal sex determination to promote a transgenerational prostate disease phenotype was investigated in the current study. METHODS: Exposure of an F0 gestating female rat to the endocrine disruptor vinclozolin during F1 embryo gonadal sex determination promoted a transgenerational adult onset prostate disease phenotype. [...]
Cardiovascular and metabolic effects of obesity.
Monday, March 3rd, 2008Morris MJClin Exp Pharmacol Physiol (Apr 2008)
1. Obesity is an important risk factor for hypertension and its incidence is increasing around the world. 2. The mechanisms underlying obesity-related hypertension include sympathetic activation, altered vascular responses, hormonal changes, enhanced inflammatory markers and structural changes. 3. This review summarizes recent evidence of the underlying impact of obesity on [...]
Environment, diet and CpG island methylation: Epigenetic signals in gastrointestinal neoplasia.
Friday, February 29th, 2008Johnson IT, Belshaw NJFood Chem Toxicol (Apr 2008)
The epithelial surfaces of the mammalian alimentary tract are characterised by very high rates of cell proliferation and DNA synthesis, and in humans they are highly susceptible to cancer. The role of somatic mutations as drivers of carcinogenesis in the alimentary tract is well established, but the importance of gene [...]
Positive histone marks are associated with active transcription from a methylated ICSBP/IRF8 gene.
Friday, February 29th, 2008Tshuikina M, Nilsson K, Oberg FGene (Mar 2008)
Epigenetic modifications are critical for regulating many different aspects of normal cell biology and tumourigenesis. Gene expression may be epigenetically silenced by DNA-methylation and histone modifications, resulting in remodelling of chromatin into a repressed state. We performed DNA-methylation analysis of the ICSBP/IRF8 gene, a member of the IRF family of transcriptional [...]
Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells.
Friday, February 29th, 2008Khan AN, Gregorie CJ, Tomasi TBCancer Immunol Immunother (May 2008)
Histone deacetylase inhibitors (HDACi), including trichostatin A (TSA) and valproic acid, can alter the acetylation of histones in chromatin and enhance gene transcription. Previously we demonstrated that HDACi-treated tumor cells are capable of presenting antigen via the MHC class II pathway. In this study, we show that treatment with [...]
Epigenetic regulation of Hox gene activation: the waltz of methyls.
Friday, February 29th, 2008Soshnikova N, Duboule DBioessays (Mar 2008)
Genetic studies have revealed that the antagonistic interplay between PcG and TrxG/MLL complexes is essential for the proper maintenance of vertebrate Hox gene expression in time and space. Hox genes must be silenced in totipotent embryonic stem cells and, in contrast, rapidly activated during embryogenesis. Here we discuss some recently published articles1-4 [...]
Towards an integrated understanding of the structure and mechanics of the cell nucleus.
Friday, February 29th, 2008Rowat AC, Lammerding J, Herrmann H, Aebi UBioessays (Mar 2008)
Changes in the shape and structural organization of the cell nucleus occur during many fundamental processes including development, differentiation and aging. In many of these processes, the cell responds to physical forces by altering gene expression within the nucleus. How the nucleus itself senses and responds to such mechanical cues [...]
Cancer testis antigens in human melanoma stem cells: expression, distribution, and methylation status.
Friday, February 29th, 2008Sigalotti L, Covre A, Zabierowski S, Himes B, Colizzi F, Natali PG, Herlyn M, Maio MJ Cell Physiol (May 2008)
Neoplastic populations with stem cell potential have been most recently identified in human cutaneous melanoma, and initially characterized for their phenotypic profile. Being melanoma stem cells (MSC) the most desirable target of therapeutic intervention, we asked whether they express the epigenetically-regulated cancer testis antigens [...]
The XVth World Congress of Psychiatric Genetics, October 7-11, 2007: Rapporteur summaries of oral presentations.
Friday, February 29th, 2008Alkelai A, Baum A, Carless M, Crowley J, Dasbanerjee T, Dempster E, Docherty S, Hare E, Galsworthy MJ, Grover D, Glubb D, Karlsson R, Mill J, Sen S, Quinones MP, Vallender EJ, Verma R, Vijayan NN, Villafuerte S, Voineskos AN, Volk H, Yu L, Zimmermann P, Delisi LEAm J Med Genet B Neuropsychiatr Genet (Mar 2008)
The World Congress of Psychiatric Genetics (WCPG) has become an annual event since the early 1990’s sponsored by the International Society of Psychiatric Genetics [...]
Methylation status of putative differentially methylated regions of porcine IGF2 and H19.
Friday, February 29th, 2008Han DW, Im YB, Do JT, Gupta MK, Uhm SJ, Kim JH, Schler HR, Lee HTMol Reprod Dev (May 2008)
This study was designed to identify the putative differentially methylated regions (DMRs) of the porcine imprinted genes insulin-like growth factor 2 and H19 (IGF2-H19), and to assess the genomic imprinting status of IGF2-H19 by identifying the methylation patterns of these regions in germ cells, [...]
Transgenerational effects of the endocrine disruptor vinclozolin on the prostate transcriptome and adult onset disease.
Friday, February 29th, 2008Anway MD, Skinner MKProstate (Apr 2008)
PURPOSE: The ability of an endocrine disruptor exposure during gonadal sex determination to promote a transgenerational prostate disease phenotype was investigated in the current study. METHODS: Exposure of an F0 gestating female rat to the endocrine disruptor vinclozolin during F1 embryo gonadal sex determination promoted a transgenerational adult onset prostate disease phenotype. [...]
