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Epigenetic Map of Human Chromosomes 6, 20, and 22 Released

By Trevor | June 26, 2006

Epigenomics AG and the Wellcome Trust Sanger Institute have released new data mapping the epigenetic state of human chromosomes 6, 20, and 22, providing the first tangible product of the Human Epigenome Project (HEP).

The analysis was completed using 43 human samples, and examined the methylation patterns in 12 different tissues. This was done in part to identify genes that are differentially methylated between DNA from various human tissues, which could affect gene expression.

Thus far, Epigenomics claims that the data is exciting because after examining over 2,500 different genomic loci, it found that “21 percent of all loci, or 17 percent of all genes on these chromosomes are differentially methylated in at least one of the examined tissue.” The company plans to publish details of these differentially methylated locations in the coming months.

The results of the whole chromosome analysis are patented. However, the methylation states of these three human chromosomes are available today through the Human Epigenome Project web site for use by non-commercial research groups. Link

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