Epigenetic remodeling of the fungal secondary metabolome.
May 29, 2008 research articles
Williams RB, Henrikson JC, Hoover AR, Lee AE, Cichewicz RH
Org Biomol Chem (Jun 2008)
Fungi treated with DNA methyltransferase and histone deacetylase inhibitors exhibited natural product profiles with enhanced chemical diversity demonstrating that small-molecule epigenetic modifiers are effective tools for rationally controlling the native expression of fungal biosynthetic pathways and generating new biomolecules.
